Project Peach
Green Light Pharmacy Logo
We use cookies to enhance your browsing experience. By clicking 'I Understand and Accept', you consent to our use of cookies.
I understand and accept
No, I don't want to use cookies
My Account
Control Panel
An example toast message
Do Something
Login
en
en
Green Light Pharmacy LogoGreen Light Pharmacy Logo
Menu
en
en
Change Language
Login
My Account
Control Panel
Order
Book
Services
Travel Clinic
Weight Loss
Branches
Log Out
Order
Book
Login
Login
en
en
Do Something
Login
en
en
Green Light Pharmacy LogoGreen Light Pharmacy Logo
Menu
en
en
Change Language
Login
My Account
Control Panel
Order
Book
Services
Travel Clinic
Weight Loss
Branches
Log Out
Order
Book
Login
Login
en
en
Tuberous sclerosis
Tuberous sclerosis

Tuberous sclerosis, also known as tuberous sclerosis complex, is a rare genetic condition that causes mainly non-cancerous (benign) tumours to develop in different parts of the body.

The tumours most often affect the brain, skin, kidneys, heart, eyes and lungs.

Tuberous sclerosis is present from birth, although it may not cause obvious problems immediately.

What problems can tuberous sclerosis cause?

The tumours caused by tuberous sclerosis can result in a range of associated health problems, including:

These problems can range from mild to severe, and it's possible to have only a few of these problems or a wide range. Members of the same family may be affected very differently by tuberous sclerosis. 

Read more about the features of tuberous sclerosis and diagnosing tuberous sclerosis.

What causes tuberous sclerosis?

Tuberous sclerosis is caused by changes (mutations) in either the TSC1 or TSC2 gene. These genes are involved in regulating cell growth, and the mutations lead to uncontrolled growth and multiple tumours throughout the body.

In around 3 in every 4 cases, the genetic fault occurs for no apparent reason in people without any other affected family members.

In the remaining 1 in 4 cases, the fault is passed on to a child by their parents. Only one parent needs to carry the faulty gene to pass it on, and a parent who has one of the faulty genes has a 1 in 2 chance of passing it on to each child they have.

The parent carrying the faulty gene will also have tuberous sclerosis, although sometimes it may be so mild they do not realise.

How tuberous sclerosis is treated

There is no cure for tuberous sclerosis, but there is a range of treatments for many of the problems caused by the condition.

For example:

  • epilepsy may be controlled with medicine or, in some cases, surgery
  • extra educational support can help children with learning disabilities
  • challenging behaviour and psychiatric problems – such as anxiety or depression – can be treated with behavioural interventions and medicine
  • brain tumours can be surgically removed or shrunk with medicine
  • the facial rash can be treated with laser therapy or medication applied to the skin
  • medicine can control symptoms caused by reduced kidney function and can help shrink kidney tumours
  • lung problems can be treated with medication

Research has found that a type of medicine known as an mTOR inhibitor, which interrupts the chemical reactions needed for tumours to grow, may be a useful treatment in the future.

People with tuberous sclerosis will also need to have regular tests to monitor the function of the organs that can be affected by the condition.

Read more about treating tuberous sclerosis.

Outlook

The outlook for people with tuberous sclerosis can vary considerably.

Some people have few symptoms and the condition has little effect on their life, while others – particularly those with a faulty TSC2 gene or obvious problems from an early age – can have severe and potentially life-threatening problems that require lifelong care.

Many people will have a normal lifespan, although a number of life-threatening complications can develop. These include a loss of kidney function, a serious lung infection called bronchopneumonia and a severe type of epileptic seizure called status epilepticus.

People with tuberous sclerosis may also have an increased risk of developing certain types of cancer, such as kidney cancer, but this is rare.

Tuberous Sclerosis Association (TSA)

The TSA provides information, advice and support to individuals and families affected by tuberous sclerosis.

You can visit the TSA website for more information and to access their online community. You can also contact the organisation's specialist advisers in your area.

Last Reviewed
13 December 2023
NHS websiteNHS website
Green Light Pharmacy Logo
Inspiring communities today and tomorrow
Do Something
Do Something
Menu
Pharmacy Services
Order Prescriptions
Health A-Z
Healthy Living Zone
Testimonials
Download Our App
Our Stores
Store Locator
Andrew McCoig Pharmacy
Geddes Pharmacy
Green Light Borehamwood
Green Light Bromley-by-Bow
Green Light Cricklewood
Green Light Euston
Green Light Green Lanes
Green Light Mornington Crescent
Green Light Ritchie Street
Green Light Sheperds Bush
Green Light Stamford Hill Broadway
Green Light Stamford Hill Dunsmure
Green Light Stamford Hill Oldhill Street
Green Light Stepney
Green Light Swiss Cottage
Hodgetts Pharmacy
Keencare Harrow
Keencare Victoria
Makepeace and Jackson Pharmacy
Medipharm Pharmacy
Twickenham Pharmacy
No stores found
Green Light Pharmacy © 2024
Website by bewell.uk
Privacy Policy
Cookies Policy
Terms & Conditions